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While the genetics of SLE are not very well understood, there is growing evidence for the involvement of specific genes in this complex autoimmune disease . Part of the complexity of this disease is due to the effects of both environment and genetics factors that may contribute to its development.  Further compounding our understanding of the etiology of the disease is the involvement of several organ systems.  Genetic studies of the rates of disease in families supports the genetic basis of this disease with a heritability of >66%.  Identical ( monozygotic ) twins were found to share susceptibility to the disease at >35% rate compared to fraternal ( dizygotic ) twins and other full siblings who only showed a 2–5% concordance in shared inheritance. 
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