Steroids structure and function


Side-effects from the use of steroids are extremely common and can be quite significant. Most side-effects are reversible once the athlete stops usage although serious long-term side-effects and even death have occurred as a direct result of steroid use.
    •    Decreased sperm production and sex drive
    •    Increased aggression, irritability and mood swings
    •    Liver disorders
    •    Acne
    •    Baldness (alopecia)
    •    Hypertension (high blood pressure)
    •    Raised cholesterol
    •    Gynecomastia (development of over-sized mammary glands in males)
    •    Menstrual irregularities (in women)
    •    Hirsuitism (excessive hair growth occurring in females which follows the pattern of male hair growth, . facial)
    •    Deepening of the voice
    •    Reduced immunity
    •    Possible development of tumors (wilm’s tumor, prostate carcinoma and leukemia have been reported, although a connection is not proven)

In addition to the mentioned side effects several others have been reported. In both males and females acne are frequently reported, as well as hypertrophy of sebaceous glands, increased tallow excretion, hair loss, and alopecia. There is some evidence that anabolic steroid abuse may affect the immune system, leading to a decreased effectiveness of the defense system. Steroid use decreases the glucose tolerance, while there is an increase in insulin resistance. These changes mimic Type II diabetes. These changes seem to be reversible after abstention from the drugs.

Anabolic steroid implants are allowed for veterinary use. But if someone diverts this for use in humans, it will be deemed as a distribution of a Schedule III drug leading to prosecution. The law on trenbolone differs in other countries. For instance, in Canada it is a Schedule IV drug. In Canada, all anabolic steroids are classified as Schedule IV drugs. In the UK, anabolic steroids are classified as Class C substances. Their possession can lead to a 2 year jail term, while their production and supply can lead to a 14 year jail term. But many countries do not have strict laws. In some places, you can even buy it over the counter.

Neuroactive steroids are also called as neurosteroids . They are endogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors. Neuroactive steroid refers to steroids that are synthesized by an endocrine gland that reach the brain through the bloodstream and have effects on brain function. Neurosteroids have a wide range of potential clinical applications from sedation to treatment of epilepsy and traumatic brain injury. Ganaxolone is a synthetic analog of the endogenous neurosteroid. Allopregnanolone is under investigation for the treatment of epilepsy.

Steroids structure and function

steroids structure and function

Neuroactive steroids are also called as neurosteroids . They are endogenous steroids that rapidly alter neuronal excitability through interaction with ligand-gated ion channels and other cell surface receptors. Neuroactive steroid refers to steroids that are synthesized by an endocrine gland that reach the brain through the bloodstream and have effects on brain function. Neurosteroids have a wide range of potential clinical applications from sedation to treatment of epilepsy and traumatic brain injury. Ganaxolone is a synthetic analog of the endogenous neurosteroid. Allopregnanolone is under investigation for the treatment of epilepsy.

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