Other factors such as toxicity, mercury poisoning and fluoride toxicity all contribute to hormone disruption in the body. Mercury particularly can interfere with the conversion of progesterone into cortisol. When there is a cascade of hormonal imbalances, you can almost say with certainty that heavy metal toxicity is a major causative factor. And when the symphony of hormones gets augmented, there are multiple responses and reactions that can ensue. The increased production of cholesterol is one. But realize that the elevation of cholesterol is a response to underlying biochemical imbalances, not a cause of it.
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Depending on the number and character of their functional groups, steroid molecules may show diverse reactivities. Moreover, the reactivity of a functional group varies according to its location within the molecule (for example, esters are formed readily by 3-OH groups but only with difficulty by the 11β-OH group). An important property of steroids is polarity —., their solubility in oxygen-containing solvents (., water and alcohols ) rather than hydrocarbon solvents (., hexane and benzene ). Hydroxyl, ketonic, or ionizable (capable of dissociating to form electrically charged particles) groups in a steroid molecule increase its polarity to an extent that is strongly influenced by the spatial arrangement of the atoms within the molecule.