Based on the one-on-one interactions Butters and Jimmy have had on the show, they seem to be good friends. In " Krazy Kripples ," Butters was the only person who went to see Jimmy's comedy show instead of Christopher Reeve's public appearance. In " Erection Day ," Jimmy came to Butters for advice on his erection problems, expressing that Butters is the only one he can tell who won't make fun of him for it. The two were also seen sitting together at Cartman's AIDS benefit in " Tonsil Trouble ". During Season Fifteen's episode " 1% " Jimmy and Butters form the 99% club to protest the Presidential Fitness Test results. They stand outside and picket the President's Council on Fitness, Sports & Nutrition, Colorado Division Regional Office, only the media believe they are protesting the Red Robin Restaurant. In " Funnybot ," Butters is the only person in the audience who was clapping and cheering Jimmy while everybody else was asleep. In " Going Native ," Butters reveals that he doesn't find Jimmy's jokes funny. In " A Nightmare on Face Time ," the two are seen trick-or-treating together.
In the Season 19 episode " Tweek x Craig ", Asian-American female students started drawing homoerotic " yaoi " images of Craig and Tweek depicting them as lovers. Immediately, the two try to repudiate the rumors about them prompted by this. They eventually resolve to stage a public "break-up" to end the rumors. Though Tweek fears he cannot do this believably, Craig encourages him that he indeed can. However, Tweek goes too far by claiming that Craig is a manipulative cheater, which has the effect of ruining Craig's reputation with girls. Tweek later reveals that Craig's encouragement him gave him the confidence to believe in himself. They have continued to pretend to be in relationship, as shown in episodes like " Put It Down ".