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In humans, levels of 5-HT 1A receptor activation in the brain show negative correlation with aggression, [44] and a mutation in the gene that codes for the 5-HT 2A receptor may double the risk of suicide for those with that genotype. [45] Serotonin in the brain is not usually degraded after use, but is collected by serotonergic neurons by serotonin transporters on their cell surfaces. Studies have revealed nearly 10% of total variance in anxiety-related personality depends on variations in the description of where, when and how many serotonin transporters the neurons should deploy. [46]

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