Gastric inhibitory polypeptide a gut hormone with anabolic functions

Volume 23, Number 4

Original Contribution

BMP-7 Attenuates TGF-b1-Induced Fibronectin Secretion and Apoptosis of NRK-52E Cells by the Suppression of miRNA-21 147
Zhong Yu, Xu  Zai -Chun, Han  Wun-Lun , and Zhu Yun-Yun

miRNA-497 Negatively Regulates the Growth and Motility of Chondrosarcoma Cells by Targeting Cdc25A 155
Yandong Lu,  Fangguo Li, Tao Xu, and  Jie Sun

miR-544a Promotes Breast Cancer Cell Migration and Invasion Reducing Cadherin 1 Expression 165
Pengwei Lu,  Yuanting Gu , Lin Li, Fang Wang, and  Xinguang Qiu

Inhibition of Liver Carcinoma Cell Invasion and Metastasis by Knockdown of Cullin7 In Vitro and In Vivo 171
Donghui Zhang,  Genling Yang,  Xidong Li, Cheng Xu, and  Honglei Ge

Clinical Outcome in Definitive Concurrent  Chemoradiation With Weekly Paclitaxel and Carboplatin for Locally Advanced Esophageal and Junctional Cancer 183
Vanita Noronha, Kumar  Prabhash , Amit Joshi, Vijay  Maruti Patil , Sanjay  Talole ,  Dipti Nakti , Arvind  Sahu ,  Srushti Shah,  Sarbani Ghosh- Laskar ,  Prachi S.  Patil ,  Shaesta A. Mehta, Nirmala Jambhekar , Abhishek Mahajan, and  Nilendu Purandare

FGF19 Contributes to Tumor Progression in Gastric Cancer by Promoting Migration and Invasion 197
Shuang Wang,  Daqi Zhao,  Ruihua Tian,  Hailong Shi,  Xiangming Chen,  Wenzhi Liu, and Lin Wei

Glucose-dependent insulinotropic polypeptide (GIP; gastric inhibitory polypeptide) is a 42 amino acid hormone that is produced by enteroendocrine K-cells and released into the circulation in response to nutrient stimulation. Both GIP and glucagon-like peptide-1 (GLP-1) stimulate insulin secretion in a glucose-dependent manner and are thus classified as incretins. The structure of mammalian GIP is well conserved and both the N-terminus and central region of the molecule are important for biological activity. Following secretion, GIP is metabolized by the endoprotease dipeptidyl peptidase IV (DPP-IV). In addition to its insulinotropic activity, GIP exerts a number of additional actions including promotion of growth and survival of the pancreatic beta-cell and stimulation of adipogenesis. The brain, bone, cardiovascular system, and gastrointestinal tract are additional targets of GIP. The GIP receptor is a member of the B-family of G protein-coupled receptors and activation results in the stimulation of adenylyl cyclase and Ca(2+)-independent phospholipase A(2) and activation of protein kinase (PK) A and PKB. The Mek1/2-Erk1/2 and p38 MAP kinase signaling pathways are among the downstream pathways involved in the regulation of beta-cell function. GIP also increases expression of the anti-apoptotic Bcl-2 and decreases expression of the pro-apoptotic Bax, resulting in reduced beta-cell death. In adipose tissue, GIP interacts with insulin to increase lipoprotein lipase activity and lipogenesis. There is significant interest in potential clinical applications for GIP analogs and both agonists and antagonists have been developed for preclinical studies.

Gastric inhibitory polypeptide a gut hormone with anabolic functions

gastric inhibitory polypeptide a gut hormone with anabolic functions

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