Ecdysteroid wikipedia

Ecdysteroid-phosphate Phosphatase is the first structure of a steroid phosphate phosphotase containing alpha beta folds common to members of the two histidine (2H)- Phosphatase superfamily with strong homology to the Suppressor of T-cell receptor signaling-1 (Sts-1 PGM) protein. The putative EPPase PGM active site contains signature residues shared by 2H-phosphatase enzymes, including a conserved histidine (His80) that acts as a nucleophile during catalysis . The physiological substrate ecdysone 22-phosphate was modeled in a hydrophobic cavity close to the phosphate- binding site . EPPase PGM shows limited substrate specificity with an ability to hydrolyze steroid phosphates, the phospho-tyrosine (pTyr) substrate analogue para-nitrophenylphosphate ( pNPP) and pTyr-containing peptides and proteins. It has been shown that new protein tyrosine phosphatase (PTP) activity for EPPase. Also, EPPase and its closest homologues can be grouped into a distinct subfamily in the large 2H- Phosphatase superfamily of proteins.

Ecdysone is a steroidal prohormone of the major insect molting hormone 20-hydroxyecdysone , which is secreted from the prothoracic glands . Insect molting hormones (ecdysone and its homologues) are generally called ecdysteroids . Ecdysteroids act as moulting hormones of arthropods but also occur in other related phyla where they can play different roles. In Drosophila melanogaster , an increase in ecdysone concentration induces the expression of genes coding for proteins that the larva requires, and it causes chromosome puffs (sites of high expression) to form in polytene chromosomes . Recent findings in the laboratory of Chris Q. Doe have found a novel role of this hormone in regulating temporal gene transitions within neural stem cells of the fruit fly. [1] Ecdysone and other ecdysteroids also appear in many plants mostly as a protection agent ( toxins or antifeedants) against herbivorous insects. [ citation needed ]

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Ecdysteroid wikipedia

ecdysteroid wikipedia

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