Corticosteroids during pregnancy and oral clefts

There is no evidence of safe and effective use of topical corticosteroids in pregnant mothers. Therefore, they should be used only if clearly needed. Long term use and large applications of topical corticosteroids may cause birth defects in the unborn. It is not known whether topical corticosteroids enter breast milk. Therefore, caution must be exercised before using it in nursing mothers. Topical corticosteroids should not be applied to the breasts of nursing mothers unless the mothers instructed to do so by the physician.

We identified 1257 infants with a congenital malformation (%) and 782 infants with a major malformation (%). We found that women who used >1000 microg/d ICS (n = 154) were significantly more likely (63%) to have a baby with a malformation than the 4392 women who used >0 to 1000 microg/d (adjusted risk ratio, ; 95% CI, -). On the other hand, women who used >0 to 1000 microg/d were not found to be more at risk than women who did not use ICSs during the first trimester (n = 8734). Nonsignificant trends of similar magnitude were found for major malformations.

Corticosteroids during pregnancy and oral clefts

corticosteroids during pregnancy and oral clefts

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corticosteroids during pregnancy and oral cleftscorticosteroids during pregnancy and oral cleftscorticosteroids during pregnancy and oral cleftscorticosteroids during pregnancy and oral cleftscorticosteroids during pregnancy and oral clefts

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