Fluticasone-Salmeterol , the generic form of Advair Diskus. Fluticasone Salmeterol the generic for Advair Diskus is in a class of medications called steroids. Advair is used to prevent asthma attacks and can also be used to prevent flareups or worsening of chonic obstructive plumonary disease (COPD). Fluticasone Salmeterol can also be used for other medical purposes. It works by reducing swelling in the airways. Salmeterol is in a class of medications called long-acting beta-agonists. It works by relaxing and opening air passages in the lungs, making it easier to breathe.