Despite the importance of the sun for vitamin D synthesis, it is prudent to limit exposure of skin to sunlight [ 19 ] and UV radiation from tanning beds [ 21 ]. UV radiation is a carcinogen responsible for most of the estimated million skin cancers and the 8,000 deaths due to metastatic melanoma that occur annually in the United States [ 19 ]. Lifetime cumulative UV damage to skin is also largely responsible for some age-associated dryness and other cosmetic changes. The American Academy of Dermatology advises that photoprotective measures be taken, including the use of sunscreen, whenever one is exposed to the sun [ 22 ]. Assessment of vitamin D requirements cannot address the level of sun exposure because of these public health concerns about skin cancer, and there are no studies to determine whether UVB-induced synthesis of vitamin D can occur without increased risk of skin cancer [ 1 ].
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In fasted normal men, the mean bioavailability of furosemide from LASIX Tablets and LASIX Oral Solution is 64% and 60%, respectively, of that from an intravenous injection of the drug. Although furosemide is more rapidly absorbed from the oral solution (50 minutes) than from the tablet (87 minutes), peak plasma levels and area under the plasma concentration-time curves do not differ significantly. Peak plasma concentrations increase with increasing dose but times-topeak do not differ among doses. The terminal half-life of furosemide is approximately 2 hours.