Aspirin and nonsteroidal anti inflammatory drugs

Aspirin may increase, decrease, or change the effects of many drugs. Aspirin can increase the toxicity of such drugs as methotrexate (Rheumatrex) and valproic acid (Depakote, Depakene). Taken with such blood-thinning drugs as warfarin (Coumadin) and dicumarol, aspirin can increase the risk of excessive bleeding. Aspirin counteracts the effects of certain other drugs, including angiotensin-converting enzyme (ACE) inhibitors and beta blockers, which lower blood pressure, and medicines used to treat gout (probenecid and sulfinpyrazone). Blood pressure may drop unexpectedly and cause fainting or dizziness if aspirin is taken along with nitroglycerin tablets. Aspirin may also interact with diuretics , diabetes medications, other nonsteroidal anti-inflammatory drugs (NSAIDs), seizure medications, and steroids. Anyone who is taking these drugs should ask his or her physician whether they can safely take aspirin.

During NSAID-anticoagulant concomitant treatment, clinically relevant bleeding occurred with an event rate of per 100 patient-years vs per 100 patient-years during anticoagulant use only (hazard ratio [HR], [95% CI, -]). Major bleeding during NSAID-anticoagulant treatment occurred with an event rate of per 100 patient-years, compared to per 100 patient-years during nonuse (HR, [95% CI, -]). For aspirin-anticoagulant concomitant treatment, clinically relevant bleeding occurred with an event rate of per 100 patient-years, compared to per 100 patient-years during aspirin nonuse (HR, [95% CI, -]). Major bleeding in aspirin-anticoagulant-treated patients occurred with an event rate of per 100 patient-years, compared to per 100 patient-years during aspirin nonuse (HR, [95% CI, -]). Increases in risk for clinically relevant and major bleeding were similar for rivaroxaban and enoxaparin-VKA anticoagulation regimens.

COX-2 inhibitors and gastroduodenal toxicity: Major clinical trials
COX-2 selective inhibitors: Adverse cardiovascular effects
Nonselective NSAIDs: Adverse cardiovascular effects
Nonselective NSAIDs: Overview of adverse effects
NSAIDs (including aspirin): Pathogenesis of gastroduodenal toxicity
NSAIDs (including aspirin): Primary prevention of gastroduodenal toxicity
NSAIDs (including aspirin): Role in prevention of colorectal cancer
NSAIDs (including aspirin): Secondary prevention of gastroduodenal toxicity
NSAIDs (including aspirin): Treatment of gastroduodenal toxicity
NSAIDs and acetaminophen: Effects on blood pressure and hypertension
NSAIDs: Acute kidney injury (acute renal failure)
NSAIDs: Adverse effects on the distal small bowel and colon
NSAIDs: Electrolyte complications
NSAIDs: Pharmacology and mechanism of action
NSAIDs: Therapeutic use and variability of response in adults
Overview of selective COX-2 inhibitors

Aspirin and nonsteroidal anti inflammatory drugs

aspirin and nonsteroidal anti inflammatory drugs

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