In males with delayed puberty: Various dosage regimens have been used; some call for lower dosages initially with gradual increases as puberty progresses, with or without a decrease to maintenance levels. Other regimens call for higher dosage to induce pubertal changes and lower dosage for maintenance after puberty. The chronological and skeletal ages must be taken into consideration, both in determining the initial dose and in adjusting the dose. Dosage is within the range of 50 to 200 mg every 2 to 4 weeks for a limited duration, for example, 4 to 6 months. X-rays should be taken at appropriate intervals to determine the amount of bone maturation and skeletal development (see INDICATIONS AND USAGE and WARNINGS ).
The standard free energies of hydrolysis provide a convenient means of comparing the phosphoryl transfer potential of phosphorylated compounds. Such comparisons reveal that ATP is not the only compound with a high phosphoryl transfer potential. In fact, some compounds in biological systems have a higher phosphoryl transfer potential than that of ATP. These compounds include phosphoenolpyruvate (PEP), 1,3-bisphosphoglycerate (1,3-BPG), and creatine phosphate ( Figure ). Thus, PEP can transfer its phosphoryl group to ADP to form ATP. Indeed, this is one of the ways in which ATP is generated in the breakdown of sugars ( Sections , , and ). It is significant that ATP has a phosphoryl transfer potential that is intermediate among the biologically important phosphorylated molecules ( Table ). This intermediate position enables ATP to function efficiently as a carrier of phosphoryl groups .