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DNA based repair mechanisms, stem cell-based regeneration, and autophagy of dead cells, debris, and amyloid beta plaques and tau protein, both of which are implicated in neurodegenerative diseases, are also promoted by fasting (2). Autophagy, the process of protein degradation and turnover of other cell constituents, is instrumental in maintenance of homeostasis. At the level of the brain, fasting enhances executive function and cognition, synaptic plasticity, neurogenesis, mitochondrial biogenesis, synthesis of neurotrophic factors, and ameliorates inflammation (1, 2).